Safe Botox storage and medical fridges

Storing Botox safely and correctly

Botox, short for Botulinum toxin, is a neurotoxic protein commonly used in cosmetic and medical procedures to temporarily reduce the appearance of facial wrinkles and fine lines by paralysing the underlying muscles.

Botox is also used for various medical purposes, including treating certain muscle spasms excessive sweating (hyperhidrosis), chronic migraines, overactive bladder, and even some neurological disorders.

It’s essential to note that Botox injections should only be administered by qualified medical professionals, such as dermatologists or plastic surgeons, to ensure safety.

While Botox is generally considered safe when used appropriately, it can lead to adverse effects if not administered correctly, such as drooping eyelids, asymmetrical facial expressions, or difficulty swallowing or breathing.

How should Botox be stored?

Botox should be stored in a refrigerator between 2°C and 8°C (36°F to 46°F) to maintain its potency and safety. Keep the vials protected from light and store them in their original packaging to prevent contamination. Handle Botox vials carefully to avoid breakage, and always check the expiration date before use. Adhering to these storage guidelines ensures the effectiveness and safety of Botox injections for patients undergoing cosmetic or medical treatments.

Are there any risks or side effects associated with improperly refrigerated Botox?

There are risks and potential side effects if Botox is not stored between the recommended cold chain temperatures. Our medical fridges are designed to help mitigate these risks through consistent temperature maintenance. Our medical fridges include built-in temperature monitors and an external temperature display, so you can easily keep an eye on a fridge’s internal temperature.

If Botox is exposed to temperatures outside the recommended range, it could compromise the sterility of the product, increasing the risk of contamination or infection when administered. 

How long can Botox be refrigerated before it expires/ what temperature range should it be sorted at?

Botox may be stored in a CoolMed medical refrigerator for up to four weeks, with the appliance consistently maintaining a controlled temperature ranging from +2°C to +8°C. 

Can Botox be frozen for long-term storage, or is refrigeration sufficient?

No, Botox should not be frozen for long-term storage. To maintain its efficacy, Botox must be stored in a refrigerator at a temperature range between 2 to 8 degrees Celsius. It is crucial to always adhere to the manufacturer’s recommended storage guidelines to ensure the product’s integrity up to its expiration date. 

What precautions should be taken to ensure the safety and efficacy of refrigerated Botox?

To guarantee the safety and effectiveness of Botox that is being refrigerated, the following precautions should be observed:

  • Correct storage temperature: Botox should be stored in a medical-grade refrigerator, which maintains a consistent temperature range between 2 to 8 degrees Celsius.
  • Original packaging: Keep Botox in its original packaging to safeguard it from light and minimise potential contamination.
  • Monitoring: Regularly monitor the fridge temperature to ensure the temperature remains within the safe range for Botox storage, using a data logger to guarantee precise temperature control data collection.
  • Avoid freezing: Never freeze Botox, as this can degrade the product, rendering it ineffective.
  • Timely use: Use reconstituted Botox within the manufacturer guide’s recommended time frame, usually within 24 hours to ensure full efficacy. 
  • Compliance with guidelines: Always follow the specific storage and handling guidelines provided by your chosen Botox manufacturer, as these may vary with different brands.

Are there visible signs that Botox has been compromised by improper refrigeration?

Products such as Botox do not typically change in appearance when they have been improperly stored, so there may be no visible signs to indicate that the product has been compromised. If you suspect the Botox has been improperly stored, it’s safest not to use the product and consult with the supplier or manufacturer.

What measures should be taken to prevent contamination of refrigerated Botox during storage or use?

  1. Store the botox in a medical-grade refrigerator at the recommended temperature range.
  2. Keep Botox within its original packaging until use.
  3. Follow strict hygiene practices, including regular handwashing and ensure you are using sterile equipment.
  4. Minimise the time Botox is kept outside of the refrigerator before use.
  5. Use aseptic techniques when preparing and administering Botox.
  6. Discard any reconstituted Botox that has not been used within the manufacturer’s advised time frame.

Are there any special considerations for transporting Botox that has been refrigerated?

  1. Ensure Botox is kept at the manufacturer’s recommended temperature range (2 to 8°C) throughout transport.
  2. Use a validated cold chain transportation method, such as insulated containers with coolant packs, to ensure temperature stability and full efficacy.
  3. Avoid exposing Botox to temperatures outside the recommended safe range to prevent potency loss.
  4. Transport Botox swiftly and directly to minimise the product’s time outside of temperature-controlled conditions.
  5. Upon arrival, immediately place Botox back into the relevant temperature-controlled medical refrigerator to re-establish optimal storage conditions.

What steps should be taken if there is a power outage or malfunction of the refrigerator containing Botox?

In the event of a power outage or refrigerator malfunction follow the below steps to mitigate any potential risks and ensure full product efficacy:

  1. Monitor the fridge’s internal temperature to determine if it remains safe and in the recommended temperature range for Botox storage. This will still be available in event of power cut due to the fridges battery back up.
  2. Implement contingency plans such as transferring Botox to an alternative medical fridge or another backup cooling system.
  3. If the temperature deviates from the recommended range, assess the duration of the temperature excursion.
  4. Consult the Botox manufacturer’s guidelines for advice on the product’s viability after a temperature breach.
  5. Record the incident details, including the duration and temperature exposure, for future reference and decision-making.


Our medical fridges provide an ideal solution for temperature-controlled storage of Botox and other cosmetic materials. With precise temperature control and reliable performance, our fridges ensure that your Botox remains potent and safe for use, giving you peace of mind and confidence in your cosmetic procedures. Trust CoolMed for optimal storage solutions that meet the highest standards of quality and safety.